A total of 7 genes & proteins are tested

With ColonArray Basic we focus on the 3 genes and the 4 proteins (MMRs) that show the most frequent genetic mutation and instability in colorectal cancer.

Panel consists of KRAS, NRAS, BRAF, MMR/MSI (MLH1, MSH2, PMS2, MSH6)

Consult your Oncologist in order to get the best possible choice for you and a personalized treatment. Further personalization of exams is possible.

If your sample is not already in MicroDiagnostics’ Ltd file. Contact us immediately to arrange for safe and fast shipping to our laboratory. You will also need to complete easily and quickly the Consent Form.

A total of 28 genes & proteins are tested

With ColonArray Broad in addition to the aforementioned 3 genes and 4 Basic proteins, an additional 19 genes and 2 proteins are added to the panel, in order to be controlled for the presence of mutations and protein expression status, providing an even more detailed and broad molecular profile of colorectal cancer.

Consult your Oncologist in order to get the best possible choice for you and a personalized treatment. Further personalization of exams is possible.

By analyzing many genes and proteins at the same time, this test offers a detailed molecular profile of colorectal cancer, on the basis of which your oncologist will choose the optimal treatment for you individually.

Consult your Oncologist in order to get the best possible choice for you and a personalized treatment.
The cancer of the colon intestine may provoke mutations in genes KRAS, NRAS, BRAF, PTEN, PI3K, HER2 and display microsatellite instability in the genes MLH1, MSH2, PMS2, MSH6.

Special treatments (targeted therapy) are available against these genetic abnormalities. In this way, the proliferation of cancer cells is restricted or the body’s most effective immune response to cancer is assured.

The tests are performed on the surgical specimen (paraffin block) that your histological examination was performed on. In our fully vertical Laboratory, the pathologist chooses the most appropriate & representative paraffin block, ensuring that the most appropriate specimen will be used for examinations. Qualitative and quantitative parameters are checked.

At our vertically integrated Laboratory, we handle your sample in such a way as to minimize its unnecessary waste:

• The paraffin block is positioned if it is possible once in the microtome to obtain tissue sections by experienced web technologists.
• Tissue sections are sequentially acquired in such way as to provide unstained tissue sections for immunohistochemistry diagnosis, if required.
• Ensure maintenance of tissue sections for further molecular testing.
• Pathologists perform microdissection, in order to ensure the highest possible amount of cancer cells, removing all other necrotic cells or normal tissue that could affect the validity of the results.
• Directly, the molecular biologist treats the tissue in a completely controlled environment with next generation sequencing (NGS), or polymerase chain reaction of real time (Real – time PCR) for the detection of mutations in genes of interest, or by immunohistochemistry method (IHC) on a certified platform.

MSI is more common in colorectal cancer and endometrial cancer. MSI has also been observed in cervical cancer, stomach cancer, glioblastoma, melanoma, ovarian cancer, prostate cancer.