"... genomic analysis in the absence of histopathological assessment
risks creating vague results"
A valuable histopathological examination for both the clinician and the patient includes a diagnostic algorithm that incorporates conventional histopathology with immunohistochemistry and molecular tests related to the disease.
The reason we offer trustworthy pathology services
It is a matter of Quality & Management
– patients deserve the best we can offer them – successful patient management starts with precision medicine, while individualized medicine requires reliable molecular tests of individual utility
– pioneers in the diagnosis & translational genomics
– because we combine morphology (phenotype) with genotype
– combining the image of the tumor, with the expression of the protein, with its molecular identity
– within the same laboratory, a team of pathologists, molecular biologists, histotechnologists
– because we avoid unnecessary time delays
– because we strategically manage the patient’s biosample at all stages within our laboratory
– we know, because we produce the block, we guarantee proper enrichment, excellent macroscopy, reliable molecular signature
– we guarantee controlled storage conditions
– we provide an integrated pathology report and a unified archive of samples-genetic material
Unique Quality Features
High level automated workflow
Laboratory Information System (AP-LIS) with full tracking & traceability:
• Barcode marking (elimination of mismatch identification problems)
Production of paraffin block, diagnosis, prognostic & predictive tests within the laboratory
One-Touch approach (avoidance of tissue waste)
Possibility of reflex testing
(reduction of response time)
External Quality Assessment (EQA)
ISO 15189 accreditation
Learn more about the Quality & Strategic Management Procedures, and the advantages of microDiagnostics Ltd
In the integrated laboratory of microDiagnostics Ltd:
– in the microscopic analysis of the tissue with the usage of additional special techniques; (e.g. histochemical, immunohistochemical and molecular tests) and
– in clinical data,
In MicroDiagnostics Ltd, from the receipt of the sample, the establishment of diagnosis up to the completion of the molecular profile of the disease, the procedure is governed by the principles of Quality Assurance in conducting all medical tests, according to the ISO: 15189 model for clinical trials.
- is fully tracked at all stages of processing within the microDiagnostics’ Ltd laboratory
- is registered with a unique number and a barcode
Each step of the process, the available results during the performance of multiple tests, the performer of each procedure (secretariat, histologist, pathologist, molecular biologist) are recorded in detail under the status of each case.
In MicroDiagnostics Ltd, the quality assurance of all the tests offered is achieved by performing regular internal checks.
They concern the vertical inspection where the application of the Quality System in a specific test is checked and includes the whole process that is applied, and the horizontal inspection where the implementation of the Procedures/Instructions that have been established is inspected.
The quality assurance team also organizes the reassessment of the already completed cases by the medical team in order to control the required Repeatability & Reproducibility of results.
All accredited tests are subject to procedural controls by European entities (LABQUALITY, ESP, UKNEQAS) on a systematic, annual basis, a procedure that ensures results of a high Quality.
Frequently Asked Questions (FAQ)
Most of the times, the sample material we are called to handle, is minimum because it has resulted from a minimally invasive method (needle biopsy, fluid puncture, FANB, EBUS, e.t.c.).
In our laboratory, pathologists check if the material is sufficient. If so, then a management algorithm follows, in order to:
to perform multiple tests on the material (Immunohistochemistry, real-time PCR, NGS) to fully highlight the molecular profile of your tumor (proteins, genes, histological Grading)
At our Integrated Pathology Laboratory, we handle your sample in such a way as to minimize unnecessary waste:
- Your sample is being processed once (and not repeatedly) by experienced histotechnologists, after its adequacy is checked by the Pathologist.
- Tissue sections are obtained successively in such a way as to ensure interpretations diagnosis, and performance of immunohistochemistry & molecular tests, where necessary.
- Careful handling and enrichment to ensure the maximum possible number of cancer cells is present, which could affect the validity of the results, a work performed by pathologists.
- The molecular biologist immediately processes the sample in a fully controlled environment, using next-generation sequencing (NGS) or real-time PCR to detect mutations in the genes of interest, or by the method of immunohistochemistry (IHC) on a certified platform to detect & evaluate tumor protein expression.
In this case and if the enrichment manipulations of the sample have been ceased, we contact your clinical doctor to discuss alternative approaches in order to extract the desired information for the optimal treatment for you. Some examples:
Perform an alternative test (e.g. Immunohistochemistry instead of PCR, or Next Generation Sequencing – NGS)
Implementation of Immunohistochemistry instead of FISH (Fluorescent In Situ Hybridization)
Possible blood sampling instead of tissue testing (liquid biopsy)
Possibility of a new biopsy or puncture (FNAB, EBUS, e.t.c.)
The processing of your sample is done by experienced Histotechnologists and Pathologists.
Molecular tests are performed by Molecular Biologists.
The results of all tests (immunohistochemistry, molecular biomarkers, cytogenetics) are evaluated and interpreted by Pathologists in order to compile and integrate the final Findings
Pathologists and Molecular Biologists regularly participate on a weekly basis in a Multidisciplinary Tumor Board (MTD), where all the medical specialties involved combine their findings, aiming at the best treatment decision for you.
Through constant contact and communication with your treating physicians (Oncologist, Surgeon, Interventional Radiologist, Radiotherapist, etc.) and within the framework of Multidisciplinary Meetings, to select or decide the following:
the available sample,
the prognostic & predictive profile of the disease